Viscoelastic properties of human and bovine articular cartilage : a comparison of frequency-dependent trends

Acknowledgments The authors would like to thank Spencer C. Barnes and Hamid Sadeghi for assistance during experimentation. We would also like to thank patients donating tissue and the surgeons collecting these. Funding The equipment used in this study was funded by Arthritis Research UK (Grant number H0671). We are grateful to Arthritis Research UK for the award of a PhD studentship to Anna A. Cederlund (Grant number 19971). Arthritis Research UK had no role in the design of the study and collection, analysis and interpretation of data and in writing the manuscript.Peer reviewedPublisher PD

Subchondral bone — a welcome distraction in OA treatment

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Osteoarthritis as an organ disease : from the cradle to the grave

We thank all the members, past and present, of the Orthopaedics Research Group whose work forms our contribution to the quest for a solution to this most disabling disease. We also wish to thank all our surgical colleagues in NHS Grampian who have kindly allowed us to use tissue donated by their patients and provided many stimulating clinical insights. We are grateful to the Medical Research Council, the Arthritis Research Campaign, the Engineering and Physical Sciences Research Council, the Sir Halley Stewart Trust and The Health Foundation for funding research related to this work. We acknowledge grant funding from TMRI Ltd. for some of the SSM studies.Peer reviewedPublisher PD

Viscoelastic deformation of articular cartilage during impact loading

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Effects of deleting cannabinoid receptor-2 on mechanical and material properties of cortical and trabecular bone

Acknowledgements We thank Dr J.S. Gregory for assistance with Image J and Mr K. Mackenzie for assistance with Micro-CT analysis. Funding ABK was funded by a University of Aberdeen, Institute of Medical Sciences studentship and the Overseas Research Students Awards Scheme.Peer reviewedPublisher PD

Modeling the effect of variation in sagittal curvature on the force required to produce a follower load in the lumbar spine

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Cyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation following an impact load in vitro

This study investigated the release of prostaglandin E2 (PGE2) from cartilage following an impact load in vitro and the possible chondroprotective effect of cyclooxygenase-2 (COX-2) inhibition using non-steroidal anti-inflammatory drugs (NSAIDs)

Mechanical and material properties of cortical and trabecular bone from cannabinoid receptor-1-null (Cnr1-/-) mice

Funding ABK was funded by a studentship from the University of Aberdeen, Institute of Medical Sciences, and the Overseas Research Students Awards Scheme Acknowledgments We are grateful to Dr J.S. Gregory for assistance with Image J and Mr K. Mackenzie for assistance with Micro-CT analysis.Peer reviewedPostprin

A comparison of cortical and trabecular bone from C57 Black 6 mice using Raman spectroscopy

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High levels of fat and (n-6) fatty acids in cancellous bone in osteoarthritis

BACKGROUND: Osteoarthritis (OA) is strongly linked with obesity and patients with osteoporosis (OP) have a low body mass index. Anecdotal evidence, clinical and laboratory, suggests that OA bone contains more fat. However, conversion of osteoblasts to adipocytes is reported in OP and this would suggest that the more porous OP cancellous bone would have a high fat content. OBJECTIVES: To test the hypothesis that OA bone contains more fat than OP bone. METHODS: Cores of cancellous bone were obtained from femoral heads of patients undergoing surgery for either OA or OP. Lipids were extracted using chloroform-methanol, weighed and expressed as a fraction of core mass and volume. A fatty acid analysis was performed using gas chromatography. RESULTS: OA bone contained twice as much fat per unit volume of tissue as OP. Levels of n-6 fatty acids were elevated in OA, especially arachidonic acid (C20:4 n-6) which was almost double that found in OP. CONCLUSIONS: These data support the hypothesis that lipids may play a significant role in the pathogenesis of OA and may provide part of the key to understanding why OA and OP lie at opposite ends of the spectrum of bone masses